Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response
Identifieur interne : 004762 ( Main/Exploration ); précédent : 004761; suivant : 004763Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response
Auteurs : Matthew T. Wolf [États-Unis] ; Christopher A. Carruthers [États-Unis] ; Christopher L. Dearth [États-Unis] ; Peter M. Crapo [États-Unis] ; Alexander Huber [États-Unis] ; Olivia A. Burnsed ; Ricardo Londono [États-Unis] ; Scott A. Johnson [États-Unis] ; Kerry A. Daly [États-Unis] ; Elizabeth C. Stahl [États-Unis] ; John M. Freund [États-Unis] ; Christopher J. Medberry [États-Unis] ; Lisa E. Carey [États-Unis] ; Alejandro Nieponice [États-Unis] ; Nicholas J. Amoroso [États-Unis] ; Stephen F. Badylak [États-Unis]Source :
- Journal of Biomedical Materials Research Part A [ 1549-3296 ] ; 2014-01.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Réaction à corps étranger.
- métabolisme : Réaction à corps étranger.
- Animaux, Femelle, Filet chirurgical, Matrice extracellulaire, Matériaux revêtus, biocompatibles, Polypropylènes, Rat Sprague-Dawley, Rats, Test de matériaux.
- Pascal (Inist)
- Wicri :
- geographic : Tulle.
- topic : Biomatériau, Chirurgie.
English descriptors
- KwdEn :
- Animals, Biomaterial, Biomedical engineering, Coated Materials, Biocompatible (chemistry), Coated material, Extracellular Matrix (chemistry), Extracellular matrix, Female, Foreign body response, Foreign-Body Reaction (metabolism), Foreign-Body Reaction (pathology), Materials Testing, Mesh, Olefin polymer, Polypropylenes (chemistry), Propylene polymer, Rats, Rats, Sprague-Dawley, Surgery, Surgical Mesh, Treatment.
- MESH :
- chemical , chemistry : Coated Materials, Biocompatible, Polypropylenes.
- chemistry : Extracellular Matrix.
- metabolism : Foreign-Body Reaction.
- pathology : Foreign-Body Reaction.
- Animals, Female, Materials Testing, Rats, Rats, Sprague-Dawley, Surgical Mesh.
Abstract
Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These materials provide robust mechanical strength and are quickly incorporated into host tissue; factors that contribute to reduced hernia recurrence rates. However, such mesh devices cause a foreign body response with the associated complications of fibrosis and patient discomfort. In contrast, surgical mesh devices composed of naturally occurring extracellular matrix (ECM) are associated with constructive tissue remodeling, but lack the mechanical strength of synthetic materials. A method for applying a porcine dermal ECM hydrogel coating to a polypropylene mesh is described herein with the associated effects upon the host tissue response and biaxial mechanical behavior. Uncoated and ECM coated heavy‐weight BARD™ Mesh were compared to the light‐weight ULTRAPRO™ and BARD™ Soft Mesh devices in a rat partial thickness abdominal defect overlay model. The ECM coated mesh attenuated the pro‐inflammatory response compared to all other devices, with a reduced cell accumulation and fewer foreign body giant cells. The ECM coating degraded by 35 days, and was replaced with loose connective tissue compared to the dense collagenous tissue associated with the uncoated polypropylene mesh device. Biaxial mechanical characterization showed that all of the mesh devices were of similar isotropic stiffness. Upon explanation, the light‐weight mesh devices were more compliant than the coated or uncoated heavy‐weight devices. This study shows that an ECM coating alters the default host response to a polypropylene mesh, but not the mechanical properties in an acute in vivo abdominal repair model. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 234–246, 2014.
Url:
- https://api.istex.fr/document/4C2D323109891109C28808CEA1C92AA99D5A4ED1/fulltext/pdf
- https://api.istex.fr/document/DE05C7B82327DB78823D9B90E90001FBC590B926/fulltext/pdf
DOI: 10.1002/jbm.a.34671
Affiliations:
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Stahl</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Freund, John M" sort="Freund, John M" uniqKey="Freund J" first="John M." last="Freund">John M. Freund</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Medberry, Christopher J" sort="Medberry, Christopher J" uniqKey="Medberry C" first="Christopher J." last="Medberry">Christopher J. Medberry</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Carey, Lisa E" sort="Carey, Lisa E" uniqKey="Carey L" first="Lisa E." last="Carey">Lisa E. Carey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Nieponice, Alejandro" sort="Nieponice, Alejandro" uniqKey="Nieponice A" first="Alejandro" last="Nieponice">Alejandro Nieponice</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>Department of Surgery, University of Pittsburgh, Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Amoroso, Nicholas J" sort="Amoroso, Nicholas J" uniqKey="Amoroso N" first="Nicholas J." last="Amoroso">Nicholas J. Amoroso</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Badylak, Stephen F" sort="Badylak, Stephen F" uniqKey="Badylak S" first="Stephen F." last="Badylak">Stephen F. Badylak</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>Department of Surgery, University of Pittsburgh, Pennsylvania</wicri:orgArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Biomedical Materials Research Part A</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A</title><idno type="ISSN">1549-3296</idno><idno type="eISSN">1552-4965</idno><imprint><biblScope unit="vol">102</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="234">234</biblScope><biblScope unit="page" to="246">246</biblScope><biblScope unit="page-count">13</biblScope><date type="published" when="2014-01">2014-01</date></imprint><idno type="ISSN">1549-3296</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1549-3296</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomaterial</term><term>Biomedical engineering</term><term>Coated Materials, Biocompatible (chemistry)</term><term>Coated material</term><term>Extracellular Matrix (chemistry)</term><term>Extracellular matrix</term><term>Female</term><term>Foreign body response</term><term>Foreign-Body Reaction (metabolism)</term><term>Foreign-Body Reaction (pathology)</term><term>Materials Testing</term><term>Mesh</term><term>Olefin polymer</term><term>Polypropylenes (chemistry)</term><term>Propylene polymer</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Surgery</term><term>Surgical Mesh</term><term>Treatment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Filet chirurgical</term><term>Matrice extracellulaire ()</term><term>Matériaux revêtus, biocompatibles ()</term><term>Polypropylènes ()</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Réaction à corps étranger (anatomopathologie)</term><term>Réaction à corps étranger (métabolisme)</term><term>Test de matériaux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Coated Materials, Biocompatible</term><term>Polypropylenes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Réaction à corps étranger</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Extracellular Matrix</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Foreign-Body Reaction</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Réaction à corps étranger</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Foreign-Body Reaction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Materials Testing</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Surgical Mesh</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Filet chirurgical</term><term>Matrice extracellulaire</term><term>Matériaux revêtus, biocompatibles</term><term>Polypropylènes</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Test de matériaux</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Biomatériau</term><term>Chirurgie</term><term>Génie biomédical</term><term>Matrice extracellulaire</term><term>Matériau revêtu</term><term>Oléfine polymère</term><term>Propène polymère</term><term>Réaction à corps étranger</term><term>Traitement</term><term>Tulle</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tulle</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Biomatériau</term><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These materials provide robust mechanical strength and are quickly incorporated into host tissue; factors that contribute to reduced hernia recurrence rates. However, such mesh devices cause a foreign body response with the associated complications of fibrosis and patient discomfort. In contrast, surgical mesh devices composed of naturally occurring extracellular matrix (ECM) are associated with constructive tissue remodeling, but lack the mechanical strength of synthetic materials. A method for applying a porcine dermal ECM hydrogel coating to a polypropylene mesh is described herein with the associated effects upon the host tissue response and biaxial mechanical behavior. Uncoated and ECM coated heavy‐weight BARD™ Mesh were compared to the light‐weight ULTRAPRO™ and BARD™ Soft Mesh devices in a rat partial thickness abdominal defect overlay model. The ECM coated mesh attenuated the pro‐inflammatory response compared to all other devices, with a reduced cell accumulation and fewer foreign body giant cells. The ECM coating degraded by 35 days, and was replaced with loose connective tissue compared to the dense collagenous tissue associated with the uncoated polypropylene mesh device. Biaxial mechanical characterization showed that all of the mesh devices were of similar isotropic stiffness. Upon explanation, the light‐weight mesh devices were more compliant than the coated or uncoated heavy‐weight devices. This study shows that an ECM coating alters the default host response to a polypropylene mesh, but not the mechanical properties in an acute in vivo abdominal repair model. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 234–246, 2014.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement></list><tree><noCountry><name sortKey="Burnsed, Olivia A" sort="Burnsed, Olivia A" uniqKey="Burnsed O" first="Olivia A." last="Burnsed">Olivia A. Burnsed</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Wolf, Matthew T" sort="Wolf, Matthew T" uniqKey="Wolf M" first="Matthew T." last="Wolf">Matthew T. Wolf</name></region><name sortKey="Amoroso, Nicholas J" sort="Amoroso, Nicholas J" uniqKey="Amoroso N" first="Nicholas J." last="Amoroso">Nicholas J. Amoroso</name><name sortKey="Amoroso, Nicholas J" sort="Amoroso, Nicholas J" uniqKey="Amoroso N" first="Nicholas J." last="Amoroso">Nicholas J. Amoroso</name><name sortKey="Badylak, Stephen F" sort="Badylak, Stephen F" uniqKey="Badylak S" first="Stephen F." last="Badylak">Stephen F. Badylak</name><name sortKey="Badylak, Stephen F" sort="Badylak, Stephen F" uniqKey="Badylak S" first="Stephen F." last="Badylak">Stephen F. Badylak</name><name sortKey="Badylak, Stephen F" sort="Badylak, Stephen F" uniqKey="Badylak S" first="Stephen F." last="Badylak">Stephen F. Badylak</name><name sortKey="Badylak, Stephen F" sort="Badylak, Stephen F" uniqKey="Badylak S" first="Stephen F." last="Badylak">Stephen F. Badylak</name><name sortKey="Carey, Lisa E" sort="Carey, Lisa E" uniqKey="Carey L" first="Lisa E." last="Carey">Lisa E. Carey</name><name sortKey="Carey, Lisa E" sort="Carey, Lisa E" uniqKey="Carey L" first="Lisa E." last="Carey">Lisa E. Carey</name><name sortKey="Carruthers, Christopher A" sort="Carruthers, Christopher A" uniqKey="Carruthers C" first="Christopher A." last="Carruthers">Christopher A. Carruthers</name><name sortKey="Carruthers, Christopher A" sort="Carruthers, Christopher A" uniqKey="Carruthers C" first="Christopher A." last="Carruthers">Christopher A. Carruthers</name><name sortKey="Crapo, Peter M" sort="Crapo, Peter M" uniqKey="Crapo P" first="Peter M." last="Crapo">Peter M. Crapo</name><name sortKey="Daly, Kerry A" sort="Daly, Kerry A" uniqKey="Daly K" first="Kerry A." last="Daly">Kerry A. Daly</name><name sortKey="Dearth, Christopher L" sort="Dearth, Christopher L" uniqKey="Dearth C" first="Christopher L." last="Dearth">Christopher L. Dearth</name><name sortKey="Dearth, Christopher L" sort="Dearth, Christopher L" uniqKey="Dearth C" first="Christopher L." last="Dearth">Christopher L. Dearth</name><name sortKey="Freund, John M" sort="Freund, John M" uniqKey="Freund J" first="John M." last="Freund">John M. Freund</name><name sortKey="Freund, John M" sort="Freund, John M" uniqKey="Freund J" first="John M." last="Freund">John M. Freund</name><name sortKey="Huber, Alexander" sort="Huber, Alexander" uniqKey="Huber A" first="Alexander" last="Huber">Alexander Huber</name><name sortKey="Johnson, Scott A" sort="Johnson, Scott A" uniqKey="Johnson S" first="Scott A." last="Johnson">Scott A. Johnson</name><name sortKey="Londono, Ricardo" sort="Londono, Ricardo" uniqKey="Londono R" first="Ricardo" last="Londono">Ricardo Londono</name><name sortKey="Medberry, Christopher J" sort="Medberry, Christopher J" uniqKey="Medberry C" first="Christopher J." last="Medberry">Christopher J. Medberry</name><name sortKey="Medberry, Christopher J" sort="Medberry, Christopher J" uniqKey="Medberry C" first="Christopher J." last="Medberry">Christopher J. Medberry</name><name sortKey="Nieponice, Alejandro" sort="Nieponice, Alejandro" uniqKey="Nieponice A" first="Alejandro" last="Nieponice">Alejandro Nieponice</name><name sortKey="Nieponice, Alejandro" sort="Nieponice, Alejandro" uniqKey="Nieponice A" first="Alejandro" last="Nieponice">Alejandro Nieponice</name><name sortKey="Stahl, Elizabeth C" sort="Stahl, Elizabeth C" uniqKey="Stahl E" first="Elizabeth C." last="Stahl">Elizabeth C. Stahl</name><name sortKey="Stahl, Elizabeth C" sort="Stahl, Elizabeth C" uniqKey="Stahl E" first="Elizabeth C." last="Stahl">Elizabeth C. Stahl</name><name sortKey="Wolf, Matthew T" sort="Wolf, Matthew T" uniqKey="Wolf M" first="Matthew T." last="Wolf">Matthew T. Wolf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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